Endocrine Abstracts

Background : Patients with primary adrenal insufficiency (PAI) describe significant impairments in quality of life. Current replacement regimes are non-physiological. Animal studies indicate that pulsatile presentation of endogenous glucocorticoids is critical for normal transcriptional and behavioural responses. Healthy volunteer work also shows that pattern of glucocorticoid presentation alters cognitive and emotional processing.Objective: To assess th...